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IL-23A & IL-12B Heterodimer Protein, Cynomolgus (HEK293, His)

IL-23A & IL-12B Heterodimer Protein, Cynomolgus (HEK293, His)

ArtNr	HY-P77703-100ug
Hersteller	MedChem Express
Menge	100 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Purity	95.0
Citations	[1]Oppmann B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000 Nov;13(5):715-25. [2]Teng MW, et al. IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nat Med. 2015 Jul;21(7):719-29. [3]Neurath MF. IL-23 in inflammatory bowel diseases and colon cancer. Cytokine Growth Factor Rev. 2019 Feb;45:1-8. [4]Murphy CA, et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med. 2003 Dec 15;198(12):1951-7. [5]Langowski JL, et al. IL-23 promotes tumour incidence and growth. Nature. 2006 Jul 27;442(7101):461-5. [6]Li Y, et al. Regulation of Memory T Cells by Interleukin-23. Int Arch Allergy Immunol. 2016;169(3):157-62. [7]Yen D, et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest. 2006 May;116(5):1310-6. [8]Chan JR, et al. IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med. 2006 Nov 27;203(12):2577-87. [9]Yago T, et al. IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res Ther. 2007;9(5):R96. [10]Parham C, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol. 2002 Jun 1;168(11):5699-708.
Smiles	VPGGSSPAWA QCQQLSQKLC TLAWSAHPLV GHMDLREEGD EETTNDVPHI QCGDGCDPQG LRDNSQFCLQ RIRQGLIFYE KLLGSDIFTG EPSLLPDSPV GQLHASLLGL SQLLQPEGHH WETQQIPSPS PSQPWQRLLL RFKILRSLQA FVAVAARVFA HGAATLSP&M WELEKDVYVV EVDWTPDAPG ETVNLTCDTP EEDDITWTSD QRHGVIGSGK TLTITVKEFL DAGQYTCHKG GETLSHSHLL LHKKENGIWS TEILKNFKNK TFLKCEAPNY SGRFTCSWLV QRNMDLKFNI KSSSSSPDSR AVTCGMASLS AEKVTLDQRD YEKYSVSCQE DVTCPTAEET LPIELALEAR QQNKYENYST SFFIRDIIKP DPPKNLQMKP LKNSQVEVSW EYPDSWSTPH SYFSLKFFVR IQRKKEKMKE TEEGCNQKGA FLVEKTSTEV QCKGGNVCVQ AQDRYYNSSC SKWACVPCRV RS
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Cynomolgus IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His),Cynomolgus,HEK293
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Product Description	IL-23 alpha and IL-12 beta are the IL-23p19 and IL-12p40 subunits, respectively, composing IL-23 via heterodimerization manner. IL-23 binds to a heterodimeric receptor composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, acts on memory CD4(+) T cells preferentially[1]. IL-23 also involves in activation of several pathways including p38 MAPK or NF-κB and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A[2]. Cynomolgus IL-23 alpha & Mouse IL-12 beta Heterodimer Protein is produced in HEK293 cells, with total length of 481 amino acids and a N-Terminal His-tag.
StorageTemperature	Stored at -20°C for 2 years
Shipping	Blue Ice
Molecular Weight	22 ( Cynomolgus IL23 alpha)&40-50 (Mouse IL12 beta) kDa
Manufacturers Product type	Recombinant Proteins

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Menge: 100 ug

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