SIGIRR Protein, Human (HEK293, His)

SIGIRR Protein functions as a negative regulator of Toll-like and IL-1R receptor signaling pathways. It inhibits recruitment of signaling components to TLR4 receptor through TIR domain interaction. SIGIRR also hinders heterodimerization of Il1R1 and IL1RAP via its extracellular domain. It interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9, TRAF6, and PALM3. Upon IL-1 stimulation, SIGIRR forms complex with IL1R1, SIGIRR, MYD88, IRAK1, and TRAF6. Similarly, upon LPC stimulation, SIGIRR is part of complex including TLR4, SIGIRR, MYD88, IRAK1, and TRAF6. SIGIRR Protein, Human (HEK293, His) is the recombinant human-derived SIGIRR protein, expressed by HEK293, with C-His labeled tag. The total length of SIGIRR Protein, Human (HEK293, His) is 118 a.a., with molecular weight of ~22-35 kDa.

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Recombinant Proteins