SARS-CoV S Protein (HEK 293, His-Myc)

The SARS-CoV S protein orchestrates viral entry by attaching the virion to the cell membrane through interactions with human ACE2 and CLEC4M/DC-SIGNR receptors. It down-regulates host tetherin (BST2) via lysosomal degradation, countering its antiviral activity. Following attachment, internalization into host cell endosomes induces S glycoprotein conformational changes, potentially unmasking the fusion peptide of S2 through cathepsin CTSL proteolysis. These processes highlight the pivotal role of the SARS-CoV S protein in viral entry and immune evasion, emphasizing its significance in SARS-CoV pathogenesis. Further investigations are crucial for understanding the underlying molecular mechanisms and identifying potential therapeutic targets. SARS-CoV S Protein (HEK293, His-Myc) is the recombinant Virus-derived SARS-CoV S protein, expressed by HEK293, with N-10*His, C-Myc labeled tag. The total length of SARS-CoV S Protein (HEK293, His-Myc) is 222 a.a., with molecular weight of ~37 kDa.

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Recombinant Proteins