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Recombinant human CTLA-4 protein

Recombinant human CTLA-4 protein

264,00 €

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ArtNr	NKM-ATGP3914-100ug
Hersteller	NKMAX
Menge	100ug
Kategorie	Oncology By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Konjugat/Tag	hIgG-His-Tag
Purity	> 95% by SDS - PAGE
Sequence	<ADL>KAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSD<L EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD> <VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDW
NCBI	NP_005205
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, ATGP3364
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Activity	Human CTLA-4 inhibits Human B7 1/CD80 induced IL-2 secretion of the Jurkat human acute T cell leukemia cells. The ED50 range ? 150 ng/ml.{ATGP3914-BA.JPG}
Antigen Species	Human
Applications info	SDS-PAGE, Bioactivity
Biological activity	The activity is determined by the IL-2 ELISA in a using Jurkat human acute T cell leukemia cells. The ED50 range ? 150 ng/ml with Human B7 1/CD80.
Concentration	0.5mg/ml (determined by Absorbance at 280nm)
Description	CTLA-4, also known as cytotoxic T-lymphocyte protein 4, is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. The affinity of CTLA-4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Recombinant human CTLA-4, fused to hIgG His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Domain	36-161aa
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Expression System	Baculovirus
Formulation	Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Gene Category	Immunology
General References	Harper K., et al. (1991) J. Immunol. 147:1037-1044. Teft WA., et al. (2006) Annu. Rev. Immunol. 24:65-97.
Molecular Weight	40.8kDa (368aa)
Storage	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

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Menge: 100ug

Listenpreis: 264,00 €

Preis: 264,00 €

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