SARS-CoV-IN-3

888958-27-8

469.74

DMSO : 7.81 mg/mL (16.63 mM; Need ultrasonic)

Anti-infection; Anti-infection; Anti-infection

SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC₅₀ of 3.6 uM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 11.7 and 20.4 nM; and IC₉₀s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 10 uM in MT-4 cells^[1]. IC50 & Target: EC50: 3.6 uM (SARS-CoV, in Vero cells)^[1]
IC50: 11.7 nM (3D7 P. falciparum), 20.4 nM (W2 P. falciparum)^[1]
IC90: 29.19 nM (3D7 P. falciparum), 56 nM (W2 P. falciparum)^[1] In Vitro: SARS-CoV-IN-3 (Compound 4) inhibits in vitro growth of Plasmodium falciparum far better than Chloroquine (CQ) ^[1].