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AITRL/TNFSF18 Protein, Mouse

AITRL/TNFSF18 Protein, Mouse

187,00 €

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ArtNr	HY-P7319-10ug
Hersteller	MedChem Express
Menge	10 ug
Kategorie	Metabolism Diabetes Cell Biology Obesity Cell Status Necrosis Apoptosis Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	95.0
Citations	[1]Tian J, et al. The Role of GITR/GITRL Interaction in Autoimmune Diseases. Front Immunol. 2020 Oct 9;11:588682. [2]Lacal PM, et al. Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion. J Pharmacol Exp Ther. 2013 Oct;347(1):164-72. [3]Wang F, et al. Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. Nat Commun. 2021 Mar 2;12(1):1378. [4]Placke T, et al. Glucocorticoid-induced TNFR-related (GITR) protein and its ligand in antitumor immunity: functional role and therapeutic modulation. Clin Dev Immunol. 2010;2010:239083. [5]Tian J, et al. Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome. J Immunol. 2019 Mar 15;202(6):1693-1703. [6]Chen M, et al. IFN-β induces the proliferation of CD4+CD25+Foxp3+ regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis. J Neuroimmunol. 2012 Jan 18;242(1-2):39-46. [7]Nocentini G, et al. Pharmacological modulation of GITRL/GITR system: therapeutic perspectives. Br J Pharmacol. 2012 Apr;165(7):2089-99. [8]Park MS, et al. The association of the activation-inducible tumor necrosis factor receptor and ligand with lumbar disc herniation. Yonsei Med J. 2007 Oct 31;48(5):839-46.
Smiles	TAIESCMVKF ELSSSKWHMT SPKPHCVNTT SDGKLKILQS GTYLIYGQVI PVDKKYIKDN APFVVQIYKK NDVLQTLMND FQILPIGGVY ELHAGDNIYL KFNSKDHIQK TNTYWGIILM PDLPFIS
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AITRL/TNFSF18 Protein, Mouse,Mouse,E. coli
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Product Description	AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases[1]. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1)[2]. AITRL/TNFSF18 Protein, Mouse is a recombinant mouse AITRL (T47-S173) without tag, which is expressed in E.coli.
StorageTemperature	Stored at -20°C for 2 years
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	Approximately 14.5 kDa
Manufacturers Product type	Recombinant Proteins

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Menge: 10 ug

Listenpreis: 187,00 €

Preis: 187,00 €

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