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AITRL/TNFSF18 Protein, Human

AITRL/TNFSF18 Protein, Human

443,00 €

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ArtNr	HY-P7318-50ug
Hersteller	MedChem Express
Menge	50 ug
Kategorie	Metabolism Diabetes Cell Biology Obesity Cell Status Necrosis Apoptosis Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	95.0
Citations	[1]Park MS, et al. The association of the activation-inducible tumor necrosis factor receptor and ligand with lumbar disc herniation. Yonsei Med J. 2007 Oct 31;48(5):839-46. [2]Tian J, et al. The Role of GITR/GITRL Interaction in Autoimmune Diseases. Front Immunol. 2020 Oct 9;11:588682. [3]Lacal PM, et al. Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion. J Pharmacol Exp Ther. 2013 Oct;347(1):164-72. [4]Wang F, et al. Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. Nat Commun. 2021 Mar 2;12(1):1378. [5]Placke T, et al. Glucocorticoid-induced TNFR-related (GITR) protein and its ligand in antitumor immunity: functional role and therapeutic modulation. Clin Dev Immunol. 2010;2010:239083. [6]Tian J, et al. Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome. J Immunol. 2019 Mar 15;202(6):1693-1703.
Smiles	METAKEPCMA KFGPLPSKWQ MASSEPPCVN KVSDWKLEIL QNGLYLIYGQ VAPNANYNDV APFEVRLYKN KDMIQTLTNK SKIQNVGGTY ELHVGDTIDL IFNSEHQVLK NNTYWGIILL ANPQFI
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AITRL/TNFSF18 Protein, Human,Human,E. coli
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Product Description	AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases[1]. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1)[2]. AITRL/TNFSF18 Protein, Human is a recombinant human AITRL (E74-I198) without tag, which is expressed in E.coli.
StorageTemperature	Stored at -20°C for 2 years
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	Approximately 14.3 kDa
Manufacturers Product type	Recombinant Proteins

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Menge: 50 ug

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Preis: 443,00 €

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