Halofuginone

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ArtNr	HY-N1584-10mM
Hersteller	MedChem Express
CAS-Nr.	55837-20-2
Menge	10 mM/1 mL
Kategorie	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Breast Cancer Hepatic Cancer
Typ	Inhibitors
Specific against	other
Purity	99.78
Formula	C16H17BrClN3O3
Citations	ACS Infect Dis. 2023 Mar 15. Br J Pharmacol. 2021 Mar 10. Cell Metab. 2023 Nov 11:S1550-4131(23)00385-6. Friedrich-Alexander University Erlangen-Nuremberg. 2023 May 2. iScience. 2023 Mar. J Tissue Eng Regen Med. 2021 Aug 7. Photodiagnosis Photodyn Ther. 2021 Oct 7;102572. Hum Gene Ther. 2021 Aug 18. [1]Tracy L McGaha, et al. Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts. J Invest Dermatol. 2002 Mar;118(3):461-70. [2]Cui Z, et al. Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone. Ann Rheum Dis. 2016 Sep;75(9):1714-21. [3]Tsuchida K, et al. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free Radic Biol Med. 2017 Feb;103:236-247. [4]Keller TL, et al. Halofuginone and other Febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7. [5]Pritesh P Jain, et al. Halofuginone, a Promising Drug for Treatment of Pulmonary Hypertension. Br J Pharmacol. 2021 Mar 10.
Smiles	O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	RU-19110
Lieferbar
Product Description	Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[1][2]. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3][4]. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[5].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
Molecular Weight	414.68
Clinical Information	Phase 2
Solubility	DMSO : 20 mg/mL (ultrasonic; adjust pH to 5 with HCl)
Isoform	Plasmodium
Pathway	Anti-infection; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad
Manufacturers Product type	Natural Products

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HY-N1584-10mM-safety-datasheet.pdf