Sivelestat

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ArtNr	HY-17443-10mg
Hersteller	MedChem Express
CAS-Nr.	127373-66-4
Menge	10 mg
Kategorie	Oncology Cardiovascular Research Atherosclerosis Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Typ	Inhibitors
Specific against	other
Purity	98.61
Formula	C20H22N2O7S
Citations	Biofabrication. 2021 Feb 1. Burns Trauma. 17 September 2021. Cancers (Basel). 2022, 14(3), 515. Cell Biosci. 2022 Jul 22;12(1):114. Ecotoxicol Environ Saf. 2023 Nov 18:268:115694. J Cell Mol Med. 2022 Feb 11. J Exp Med. 2023 Sep 4;220(9):e20221751. J Infect Dis. 2023 Nov 28:jiad526. Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121. Research Square Preprint. 2021 Aug. Research Square Preprint. 2021 Jun. Research Square Preprint. 2023 Dec 11. J Hepatocell Carcinoma. 2021 May 20;8:451-465. Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121. Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121. Oxid Med Cell Longev. 2019 Nov 23;2019:7323986. [1]Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20. [2]Yuichiro Toda, et al. A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. Int J Mol Med. 2007 Feb;19(2):237-43. [3]Tomoharu Kono, et al. Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Mol Cell Biochem. 2008 Apr;311(1-2):87-92. [4]Adeleh Sahebnasagh, et al. Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. J Clin Pharm Ther. 2020 Aug 28.
Smiles	CC(C)(C)C(OC1=CC=C(S(=O)(NC2=CC=CC=C2C(NCC(O)=O)=O)=O)C=C1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	EI546; LY544349; ONO5046
Lieferbar
Product Description	Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	434.46
Clinical Information	Launched
Solubility	DMSO : ≥ 100 mg/mL\|Ethanol : 3.03 mg/mL (ultrasonic)
Pathway	Anti-infection; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-17443-10mg-safety-datasheet.pdf