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Atorvastatin hemicalcium salt

Atorvastatin hemicalcium salt

216,00 €

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ArtNr	HY-17379-200mg
Hersteller	MedChem Express
CAS-Nr.	134523-03-8
Menge	200 mg
Kategorie	Metabolism Cholesterol & Lipid Metabolism Cardiovascular Research Atherosclerosis Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Specific against	other
Purity	99.93
Formula	C33H34Ca0.5FN2O5
Citations	Cell Death Dis. 2021 May 13;12(5):482. Endocrinology. 2018 May 1;159(5):2008-2021. Front Bioeng Biotechnol. 2022 Mar 17;10:826093. Pharmaceutics. 2022, 14(1), 176. Arterioscler Thromb Vasc Biol. 2022 May;42(5):644-658. Biomed Pharmacother. 2023 Aug 12;166:115323. Biotechnol Bioeng. 2021 Sep 3. Cancer Lett. 2022 Oct 19;215976. Cell Cycle. 2019 Dec;18(23):3337-3350. Cell Cycle. 2021 Sep 8;1-14. Endocrinology. 2022 May 18;bqac076. Eur J Pharmacol. 2023 Aug 1;956:175938. Eur J Pharmacol. 2023 Dec 21:176261. Exp Cell Res. 2023 Oct 23:113829. Front Cell Dev Biol. 2022 Mar 3;10:806081. Int J Mol Sci. 2023 Apr 19, 24(8), 7492. J Mol Neurosci. 2021 Sep 26. J Nat Prod. 2022 Jun 24. J Neuroimmunol. 2020 Oct 24;350:577429. Mol Cell. 2021 Jul 1;81(13):2736-2751.e8. Naunyn Schmiedebergs Arch Pharmacol. 2023 Jun 8. Oncogene. 2022 Oct 31. Phytomedicine. 2023 Jul 26;119:154997. Proteomics. 2023 May 4;e2300041. Research Square Preprint. 2021 Dec. Research Square Preprint. 2022 Jun. Sci Rep. 2020 Jan 28;10(1):1308. Signal Transduct Target Ther. 2023 Dec 25;8(1):457. [1]Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. [2]Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22. [3]Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. [4]Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72. [5] Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821.
Smiles	FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C(C(C)C)N2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C=C1.[0.5Ca2+]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CI-981; Atorvastatin hemicalcium
Lieferbar
Product Description	Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	577.67
Clinical Information	Launched
Solubility	DMSO : ≥ 50 mg/mL\|H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Pathway	Apoptosis; Autophagy; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-17379-200mg-safety-datasheet.pdf