Saquinavir

65,00 €

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ArtNr	HY-17007-10mg
Hersteller	MedChem Express
CAS-Nr.	127779-20-8
Menge	10 mg
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.73
Formula	C38H50N6O5
Citations	Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00872-20. Antiviral Res. 2022 Nov 10;105463. Exp Cell Res. 2019 Oct 1;383(1):111488. Int J Antimicrob Agents. 2019 Dec;54(6):814-819. J Med Chem. 2021 Mar 11;64(5):2725-2738. J Pharm Sci. 2017 Sep;106(9):2839-2846. Nat Commun. 2020 Sep 4;11(1):4417. Phytomedicine. 2019 Mar 15;56:175-182. Signal Transduct Target Ther. 2021 May 29;6(1):212. bioRxiv. 2020 Apr. [1]Marco Donia, Danijela Maksimovic-Ivanic, Sanja Mijatovic, et al. In vitro and in vivo anticancer action of Saquinavir-NO, a novel nitric oxide-derivative of the protease inhibitor saquinavir, on hormone resistant prostate cancer cells. Cell cycle. 2011, 10(3): 492 - 499. [2]Walmsley Sharon, Avihingsanon Anchalee, Slim Jihad et al. Gemini: A Noninferiority Study of Saquinavir/Ritonavir Versus Lopinavir/Ritonavir as Initial HIV-1 Therapy in Adults. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2009,50 (4) :367-374. [3]Saquinavir [4]Barillari Giovannia, Iovane Andréa, Bacigalupo Ilariaa, et al. Ritonavir or saquinavir impairs the invasion of cervical intraepithelial neoplasia cells via a reduction of MMP expression and activity. AIDS. 2012, 26 (8): 909-919. [5]Martha Stefanidou, Carolina Herrera, Naomi Armanasco et al. Saquinavir Inhibits Early Events Associated with Establishment of HIV-1 Infection: Potential Role for Protease Inhibitors in Prevention. Antimicrob. Agents Chemother. 2012, 56 (8): 4381-4390. [6]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
Smiles	O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN2[C@H](C(NC(C)(C)C)=O)C[C@@](CCCC3)([H])[C@@]3([H])C2)=O)C4=NC5=CC=CC=C5C=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Ro 31-8959
Lieferbar
Product Description	Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.36 μM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
Molecular Weight	670.84
Clinical Information	Launched
Solubility	DMSO : 100 mg/mL (ultrasonic)
Isoform	HIV-1; HIV-2
Pathway	Anti-infection; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-17007-10mg-safety-datasheet.pdf