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Eravacycline dihydrochloride

Eravacycline dihydrochloride

2.361,00 €

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ArtNr	HY-16980A-25mg
Hersteller	MedChem Express
CAS-Nr.	1334714-66-7
Menge	25 mg
Kategorie	Oncology Food Safety Antibiotics Neuroscience Neural Lineage Markers By Cell Type Blastoma Carcinoma Cell Biology Cell Status Proliferation Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Typ	Inhibitors
Specific against	other
Purity	98.98
Formula	C27H33Cl2FN4O8
Dry ice	Yes
Citations	J Antimicrob Chemother. 2021 Feb 11;76(3):653-658. Mbio. 2021 May 28;e0103121. Microb Pathog. 2020 Dec;149:104502. Pharmaceutics. 2021, 13(12), 2085. Research Square Preprint. 2022 Feb. Ann Lab Med. 2021 May 1;41(3):293-301. Antibiotics (Basel). 2022, 11(10), 1298. Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00470-19. Antimicrob Agents Chemother. 2021 May 18;65(6):e00203-21. Clin Exp Pharmacol Physiol. 2023 Apr 22. Diagn Micr Infec Dis. 2020 Nov;98(3):115129. Infect Drug Resist. 2023 Apr 17. Infect Drug Resist. 2023 Sep 7. J Antibiot (Tokyo). 2019 Aug;72(8):600-604. J Antibiot (Tokyo). 2022 Jul 27. J Antimicrob Chemother. 2021 May 6;dkab141. J Clin Microbiol. 2020 Jan 28;58(2):e01603-19. Microbiol Spectr. 2022 Dec 8;e0323822. Microbiol Spectr. 2023 May 4;e0071823. Nat Microbiol. 2023 Mar;8(3):410-423. Nat Struct Mol Biol. 2023 Aug 7. Virulence. 2022 Dec;13(1):77-88. [1]Xiao XY, et al. Fluorocyclines: a potent, broad spectrum antibacterial agent. J Med Chem. 2012 Jan 26;55(2):597-605. [2]Sutcliffe JA, et al. Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens. Antimicrob Agents Chemother. 2013 Nov;57(11):5548-58. [3]Grossman TH, et al. Eravacycline (TP-434) is efficacious in animal models of infection. Antimicrob Agents Chemother. 2015 May;59(5):2567-71. [4]Seifert H, et al. In-vitro activity of the novel fluorocycline eravacycline against carbapenem non-susceptible Acinetobacter baumannii. Int J Antimicrob Agents. 2017 Jul 10. [5]Zhao M, et al. In Vivo Pharmacodynamic Target Assessment of Eravacycline against Escherichia coli in a Murine Thigh Infection Model. Antimicrob Agents Chemother. 2017 Jun 27;61(7).
Smiles	O=C(NC(C(O)=C1C2=O)=CC(F)=C1C[C@@]3([H])C[C@@]4([H])[C@H](N(C)C)C(O)=C(C(N)=O)C([C@@]4(O)C(O)=C32)=O)CN5CCCC5.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	TP-434 dihydrochloride; TP-434-046
Lieferbar
Product Description	Eravacycline dihydrochloride (TP-434 dihydrochloride) is a potent and broad-spectrum antibacterial agent.
StorageTemperature	-80°C, protect from light, stored under nitrogen
Shipping	Dry Ice
Manufacturers Applications	COVID-19-immunoregulation
Molecular Weight	631.48
Clinical Information	Launched
Solubility	DMSO : ≥ 50 mg/mL\|H2O : 100 mg/mL (ultrasonic)
Pathway	Anti-infection
Manufacturers Product type	Reference compound

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HY-16980A-25mg-safety-datasheet.pdf