Brefeldin A

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ArtNr	HY-16592-10mM
Hersteller	MedChem Express
CAS-Nr.	20350-15-6
Menge	10 mM/1 mL
Kategorie	Oncology Neuroscience Neuroinflammation Neural Mitochondrial Function Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Breast Cancer Heart & Blood Cancer
Typ	Inhibitors
Specific against	other
Purity	99.87
Formula	C16H24O4
Citations	[1]Wang J, et al. Erythroleukemia cells acquire an alternative mitophagy capability. Sci Rep. 2016 Apr 19;6:24641. [2]Yu C, et al. Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell. 2015 Feb 5;16(2):142-7. [3]Alvarez C, et al. Brefeldin A (BFA) disrupts the organization of the microtubule and the actin cytoskeletons. Eur J Cell Biol. 1999 Jan;78(1):1-14. [4]Tseng CN, et al. Brefeldin A reduces anchorage-independent survival, cancer stem cell potential and migration of MDA-MB-231 human breast cancer cells. Molecules. 2014 Oct 29;19(11):17464-77. [5]Colanzi A, et al. Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9794-9. [6]Jensen HL, Rygaard J, Norrild B. A time-related study of Brefeldin A effects in HSV-1 infected cultured human fibroblasts. APMIS. 1995;103(7-8):530-539. doi:10.1111/j.1699-0463.1995.tb01402.x [7]Nozawa N, et al. Subcellular localization of herpes simplex virus type 1 UL51 protein and role of palmitoylation in Golgi apparatus targeting. J Virol. 2003 Mar;77(5):3204-16.
Smiles	O[C@@H]1C[C@]2([H])[C@@](/C=C/CCC[C@H](C)OC(/C=C/[C@H]2O)=O)([H])C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BFA; Cyanein; Decumbin
Lieferbar
Product Description	Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus[1][2]. Brefeldin A is also an autophagy and mitophagy inhibitor[3]. Brefeldin A is a CRISPR/Cas9 activator[5]. Brefeldin A inhibits HSV-1 and has anti-cancer activity[5].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	280.36
Clinical Information	No Development Reported
Solubility	DMSO : 100 mg/mL (ultrasonic)\|Ethanol : 11.11 mg/mL (ultrasonic)
Isoform	HSV-1
Pathway	Anti-infection; Autophagy; Cell Cycle/DNA Damage
Manufacturers Product type	Natural Products

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HY-16592-10mM-safety-datasheet.pdf