Mitoxantrone

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ArtNr	HY-13502-10mM
Hersteller	MedChem Express
CAS-Nr.	65271-80-9
Menge	10 mM/1 mL
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Breast Cancer Heart & Blood Cancer
Typ	Inhibitors
Specific against	other
Purity	98.36
Formula	C22H28N4O6
Citations	Acta Pharmacol Sin. 2022 Aug 31. Cancers. 2020 Aug 4;12(8):2169. Exp Cell Res. 2020 Aug 1;393(1):112054. Int J Biol Sci. 2022 Mar 21;18(6):2568-2582. J Am Chem Soc. 2022 Jun 15;144(23):10407-10416. J Mol Med (Berl). 2019 Aug;97(8):1183-1193. J Pharm Pharmacol. 2022 Jan 5;74(1):41-56. J Pharm Pharmacol. 23 November 2021. Pharm Dev Technol. 2021 Apr 30;1-9. Research Square Print. November 28th, 2022. bioRxiv. 2023 Jan 13. BMC Cancer. 2021 Oct 13;21(1):1101. Cell Oncol. 2020 Dec;43(6):1099-1116. Drug Deliv. 2022 Dec;29(1):2561-2578. J Mol Med (Berl). 2019 Aug;97(8):1183-1193. Med Oncol. 2020 Nov 19;37(12):116. [1]Fujimoto S, et al. Antitumor activity of mitoxantrone against murine experimental tumors: comparative analysis against various antitumor antibiotics. Cancer Chemother Pharmacol. 1982;8(2):157-62. [2]Vibet S, et al. Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines. Drug Metab Dispos. 2007 May;35(5):822-8. [3]Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7. [4]Bellosillo B, et al. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6. [5]Sharon E Altmann, et al. Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone. Antiviral Res. 2012 Feb;93(2):305-308.
Smiles	O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Mitozantrone; NSC 301739
Lieferbar
Product Description	Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity[1][2][3][4]. Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively[5].
StorageTemperature	-20°C (Powder, protect from light)
Shipping	Blue Ice
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	444.48
Clinical Information	Launched
Solubility	DMSO : 62.5 mg/mL (ultrasonic)
Isoform	PKC; Topo II
Pathway	Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; TGF-beta/Smad
Manufacturers Product type	Reference compound

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HY-13502-10mM-safety-datasheet.pdf