Cabozantinib

49,00 €

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ArtNr	HY-13016-5mg
Hersteller	MedChem Express
CAS-Nr.	849217-68-1
Menge	5 mg
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Breast Cancer Heart & Blood Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.96
Formula	C28H24FN3O5
Citations	Acta Pharmacol Sin. 2021 Jan;42(1):108-114. Adv Healthc Mater. 2023 Aug 21;e2302046. Am J Reprod Immunol. 2021 Mar;85(3):e13352. Antioxidants (Basel). 2021, 10(9), 1336. Biochem Biophys Rep. 2020 Jan 17;21:100726. Biomaterials. 16 September 2022. Biomed Chromatogr. 2020 Aug;34(8):e4862. Biomed Chromatogr. 2023 May 15;e5685. Biomedicines. 2020 Nov 28;8(12):547. bioRxiv. 2023 Apr 14. Cancer Discov. 2021 Jan;11(1):126-141. Cancer Lett. 2019 Apr 10;447:105-114. Cancers (Basel). 2024 Jan 8, 16(2), 269. Drug Des Devel Ther. 2018 Apr 30;12:1009-1017. Eur J Drug Metab Pharmacokinet. 2021 Jul 18;1-11. Exp Cell Res. 2020 Aug 1;393(1):112054. Front Oncol. 2022 Jul 7;12:915319. Fundam Clin Pharmacol. 2021 Feb 1. Int J Mol Sci. 2022 Sep 14;23(18):10677. Invest Ophthalmol Vis Sci. 2022 Dec 1;63(13):14. J Cell Biochem. 2020 Mar;121(3):2343-2353. J Med Chem. 2016 Jan 14;59(1):358-73. J Neurosci. 2020 Dec 9;40(50):9602-9616. J Pharm Anal. 2021 Jun 19. J Transl Med. 2023 Jan 9;21(1):9. Mediat Inflamm. 2020 Oct 24;2020:1649453. Mol Cancer Res. 2019 Feb;17(2):499-507. Mol Cancer Ther. 2017 Nov;16(11):2387-2398. Patent. US20170349880A1. Patent. US20220332731A1. PLoS One. 2017 Sep 25;12(9):e0185321. React Kinet Mech Cat. 07 January 2022. Saudi Pharm J. 2023 Aug 24, 101756. Sci Rep. 2019 Nov 12;9(1):16600. Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Apr 15;159:199-208. Harvard Medical School LINCS LIBRARY Virology. 2023 Jun 21. [1]Fuse MA, et al. Combination Therapy With c-Met and Src Inhibitors Induces Caspase-Dependent Apoptosis of Merlin-Deficient Schwann Cells and Suppresses Growth of Schwannoma Cells. Mol Cancer Ther. Mol Cancer Ther. 2017 Nov;16(11):2387-2398. [2]You WK, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res, 2011, 71(14), 4758-4768. [3]Yakes FM, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther, 2011, 10(12), 2298-2308.
Smiles	O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC3=CC=C(C=C3)OC4=C5C=C(OC)C(OC)=CC5=NC=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	XL184; BMS-907351
Lieferbar
Product Description	Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis[1][2].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	501.51
Clinical Information	Launched
Solubility	DMSO : 25 mg/mL (ultrasonic)\|H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Isoform	Met; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Pathway	Apoptosis; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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