Obatoclax Mesylate

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ArtNr	HY-10969-5mg
Hersteller	MedChem Express
CAS-Nr.	803712-79-0
Menge	5 mg
Kategorie	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Heart & Blood Cancer Thyroid Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.74
Formula	C21H23N3O4S
Citations	Am J Cancer Res. 2019 Mar 1;9(3):546-561. Biomed Pharmacother. 2020 Sep;129:110371. Cancer Lett. 2022 Nov 30;216028. iScience. 13 August 2022, 104925. Norwegian University of Science and Technology. Department of Clinical and Molecular Medicine. 2021 Oct. Sci Rep. 2019 Sep 24;9(1):13786. Viruses. 2020 Oct 18;12(10):1178. ACS Infect Dis. 2023 Oct 5. Acta Pharmacol Sin. 2021 Aug;42(8):1298-1310. Departamento de Biotecnología - Departament de Biotecnologia. 2020 Sep 7. [1]Sulkshane P, et al. BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells. Oncotarget. 2016 Aug 5;8(36):60060-60079. [2]Ehrenkaufer G, et al. Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity. PLoS Negl Trop Dis. 2020 Mar 20;14(3):e0008150. [3]Or CR, et al. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells. Int J Mol Sci. 2016 Dec 27;18(1). [4]Nguyen M, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7. Epub 2007 Nov 26.
Smiles	COC1=CC(C2=CC3=C(C=CC=C3)N2)=N/C1=C\C4=C(C=C(N4)C)C.CS(=O)(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GX15-070 (Mesylate)
Lieferbar
Product Description	Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2[1][2]. Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity[3][4].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	413.49
Clinical Information	Phase 3
Solubility	DMSO : 12.5 mg/mL (ultrasonic)
Isoform	Bcl-2; Bcl-B; Bcl-W; Bcl-xL; Mcl-1
Pathway	Anti-infection; Apoptosis; Autophagy
Manufacturers Product type	Reference compound

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