Motesanib

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ArtNr	HY-10228-10mM
Hersteller	MedChem Express
CAS-Nr.	453562-69-1
Menge	10 mM/1 mL
Kategorie	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Bladder Cancer
Typ	Inhibitors
Clon	N/A
Specific against	other
Purity	99.96
Formula	C22H23N5O
Citations	Cell Physiol Biochem. 2018;48(1):227-236. Harvard Medical School LINCS LIBRARY J Cell Biochem. 2020 Mar;121(3):2343-2353. Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. Oncotarget. 2016 Sep 27;7(39):63839-63855. [1]Kruser TJ, et al. Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptors. Clin Cancer Res, 2010, 16(14), 3639-3647. [2]Coxon A, et al. Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors. Clin Cancer Res, 2009, 15(1), 110-118. [3]Polverino A, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer R
Smiles	O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC(NCC4(C)C)=C4C=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AMG 706
Lieferbar
Product Description	Motesanib (AMG 706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is appr 10-fold more selective for VEGFR than PDGFR and Ret.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	373.45
Clinical Information	Phase 3
Solubility	DMSO : ≥ 100 mg/mL
Isoform	VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Pathway	Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-10228-10mM-safety-datasheet.pdf