Isradipine

Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 348 M.It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack. [1] the interactive effects ofisradipine and blockers or enhancers of nonselective cation channels (NSCCs)and Na+/Ca2+ exchangers (NCXs). Normal human gingival fibroblast Gin-1 cellswere used. The [Ca2+]i was measured with the Ca2+-sensitive fluorescent dyefura-2/AM. Changes in the fluorescence intensity of fura-2 in the cells wererecorded with a video-imaging analysis system. Ca2+ antagonists (nifedipine, verapamil, and diltiazem in the concentration range of 1 to 20 M) otherthan isradipine also raised the [Ca2+]i. [2]

Isradipine (Dynacirc) Chemical Structure

2 years -20CPowder, 2 weeks4Cin DMSO, 2 months-80Cin DMSO