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CD40L/CD154/TRAP Protein, Mouse (HEK293, Fc)

CD40L/CD154/TRAP Protein, Mouse (HEK293, Fc)

148,00 €

Zzgl. MwSt.

ArtNr	HY-P72908-50ug
Hersteller	MedChem Express
Menge	50 ug
Kategorie	Inhibitors & Compound Libraries Small Molecules
Typ	Peptides
Specific against	other
Purity	92.40
Citations	[1]Blotta MH, et al. Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J Immunol. 1996 May 1;156(9):3133-40. [2]Schwabe RF, et al. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. J Immunol. 2001 Jun 1;166(11):6812-9. [3]Batlle A, et al. CD40 and B-cell receptor signalling induce MAPK family members that can either induce or repress Bcl-6 expression. Mol Immunol. 2009 May;46(8-9):1727-35. [4]Mikolajczak SA, et al. The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells. J Exp Med. 2004 Apr 5;199(7):1025-31. [5]Takada YK, et al. Soluble CD40L activates soluble and cell-surface integrin αvβ3, α5β1, and α4β1 by binding to the allosteric ligand-binding site (site 2). J Biol Chem. 2021 Jan-Jun;296:100399. [6]Pietravalle F, et al. Human native soluble CD40L is a biologically active trimer, processed inside microsomes. J Biol Chem. 1996 Mar 15;271(11):5965-7. [7]Rahman M, et al. Platelet-derived CD40L (CD154) mediates neutrophil upregulation of Mac-1 and recruitment in septic lung injury. Ann Surg. 2009 Nov;250(5):783-90.
Smiles	GDEDPQIAAH VVSEANSNAA SVLQWAKKGY YTMKSNLVML ENGKQLTVKR EGLYYVYTQV TFCSNREPSS QRPFIVGLWL KPSSGSERIL LKAANTHSSS QLCEQQSVHL GGVFELQAGA SVFVNVTEAS QVIHRVGFSS FGLLKL
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD40L/CD154/TRAP Protein, Mouse (HEK293, Fc),Mouse,HEK293
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Product Description	CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis[1]. CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-κB/MAPK pathway[2][3]. CD40L also involves in B cell differentiation, maturation, and apoptosis[4]. CD40L in mouse, cleaved into 2 chains of membrane form (1-260 a.a.) and soluble form (112-260 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Protein, Mouse (HEK293, Fc) has a total length of 146 amino acids (G115-L260), is expressed in HEK392 cells with N-terminal hFc-tag.
StorageTemperature	Stored at -20°C for 2 years
Shipping	Blue Ice
Molecular Weight	Approximately 46.23 kDa
Manufacturers Product type	Recombinant Proteins

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Menge: 50 ug

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Preis: 148,00 €

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