SYNAPTOPHYSIN

GWB-CC989C

6855

SP15

Spleen cells from immunised BALB/c mice were fused with cells of the NSO mouse myeloma cell line.

Purified IgM prepared by gel filtration from tissue culture supernatant

Immunohistology - Paraffin - 1/25

Homohexamer or homotetramer.

Characteristic of a type of small (30-80 nm) neurosecretory vesicles including presynaptic vesicles but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (By similarity).

Contains 1 MARVEL domain. 1. Honer. W. G. et al. (1994) Hippocampal synaptic pathology in patients with temporal lobe epilepsy. 2. Honer. W. G. et al. (1992) Regional synaptic pathology in Alzheimer\' s disease. 3. Honer. W. G. et al. (1993) Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex. 4. Honer. W. G. et al. (1992) Characterization of a synaptic antigen of interest in neuropsychiatric illness. 5. Honer. W. G. et al. (1989) Monoclonal antibodies to study the brain in schizophrenia. 6. Masliah. E. et al. (1994) Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer\' s disease hippocampus. 7. Simpson. I. A. et al. (1994) Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer\' s disease. 8. Wakabayashi. K. et al. (1994) Synapse alterations in the hippocampalentorhinal formation in Alzheimer\' s disease with and without Lewy body disease. 9. Dickson. D. W. et al. (1994) Hippocampal sclerosis: a common pathological feature of dementia in very old (> 80 years of age) humans. Acta Neuropathologica 88: 212-221. 10. Dickson. D. W. et al. (1995) Correlations of synaptic and pathological markers with cognition of the elderly. 11. Dickson. D. W. et al. (1995) Correlations of synaptic markers with cognitive status in prospectively studied elderly humans. Neurobiol Aging 16:285-98.