CD57 [B321 (NK-1)]

ArtNr	20-272-193506
Hersteller	GENWAY
Menge	0.2 mg
Kategorie	Oncology Antibodies Cell Biology Cell Status Necrosis Western Blot Immunofluorescence Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	WB, IF
Clon	NK-1, B321
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-DA6B25
Similar products	20-272-193506
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Genway ID:	GWB-DA6B25
Clone:	B321 (NK-1)
Isotype:	IgM
Immunogen:	Human peripheral blood mononuclear cells.
Antigen Species:	Human
Specificity:	This antibody reacts with a 110 kD human cell surface glycoprotein known as HNK-1. This CD marker recognizes peripheral blood lymphocyte subsets and natural killer (NK) cells. Many cells which co-express CD57 and CD8 antigens are a subset of suppressor/cytotoxic T-cells. These antibodies recognize neuroendocrine cells and their tumors. CD57 antigens are not expressed on erythrocytes or platelets.
Positive Control:	Tonsil Lymph Node. Natural killer Granulocytess are located mainly in germinal centers.
Target:	CD57
Concentration:	0. 4 mg/ml Storage
Buffer:	50 mM Sodium Borate 150 mM Sodium Chloride 20% Glycerol and 0. 05% Sodium azide pH 8. 0.
Application Note:	Immunofluorescence 5-20 ug/mL. Flow cytometry 1-5 ug/10^6 cells. Immunoblotting 1-5 ug/mL. This antibody can be used on frozen cryostat sections as well as formalin-fixed paraffin-embedded tissue sections. Prolonged fixation is buffered formalin can destroy the epitope. The antibody may be used at a dilution of 5-10 ug/mL with the Auto/Probe III kit. For consistent and reproducible results on formalin-fixed paraffin-embedded sections a high temperature antigen unmasking technique is required (see instructions below). Monoclonal Mouse Anti-Human CD 57 Natural Killer Cell (Leu7 HNK-1)
Function:	Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR) asialo-fetuin and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid regardless of the length of the acyl group (By similarity).
Catalytic Activity:	UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. Cofactor: Manganese.
Pathway:	Protein modification; protein glycosylation.
Subunit:	Homodimer (Potential).
Subcellular Location:	Golgi apparatus membrane; Single-pass type II membrane protein.
Tissue Specificity:	Mainly expressed in the brain.
Similarity:	Belongs to the glycosyltransferase 43 family.

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Menge: 0.2 mg

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Lieferung vsl. bis 11.09.2025