Synaptophysin [4E206]

4E206

Synaptic vesicle-containing fractions immunoprecipitated from human brain homogenates using anti-human Synaptophysin monoclonal antibodies.

Mouse and rat brain tissue extract. No reactivity was detected in mouse liver extracts.

Integral membrane protein. Synaptic vesicles.

None. Constituents: 50% Glycerol PBS 0. 1mM PMSF. pH 7. 2

Integral membrane protein. Synaptic vesicles. Synaptophysin is a 38kDa glycoprotein present in the membrane of neuronal presynaptic vesicles in brain spinal cord retina vesicles of adrenal medulla neuromuscular junctions and endocrine cells. It is also expressed by neuroendocrine cells throughout the body both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms. This antibody reacts with neuroendocrine cells of human adrenal medulla carotid body skin pituitary gland thyroid lung pancreas and gastointestinal mucosa. It also reacts with a wide spectrum of neuroendocrine neoplasms of neural type including neuroblastomas ganglioneuroblastomas ganglioneuromas pheochromocytomas chromaffin and non-chromaffin paragangliomas.

Homohexamer or homotetramer.

Characteristic of a type of small (30-80 nm) neurosecretory vesicles including presynaptic vesicles but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (By similarity).

Contains 1 MARVEL domain.