BDNF [35928.11]

GWB-A8C32F

IgG1

Human

BDNF

0. 5 mg/ml Storage

I-ELISA: Use at a concentration of 0. 5-1 µ g/ml. WB: Use at a concentration of 1-2 µ g/ml. Predicted

Secreted Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes NGF NT3 and NT4. All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level. BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro including neural crest and placode-derived sensory neurons dopaminergic neurons in the substantia nigra basal forebrain cholinergic neurons hippocampal neurons and retinal ganglial cells. BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields raising the possibility that BDNF has paracrine or even autocrine actions on neurons as well as non-neuronal cells.

Monomers and homodimers. Binds to NTRK2/TRKB.

The propeptide is N-glycosylated and glycosulfated.

Variations in BDNF are associated with susceptybility to bulimia nervosa 2 (BULN2) [MIM:610269]. Several genes with an essential role in the regulation of eating behavior and body weight are considered candidates involved in the etiology of eating disorders (ED) but no relevant susceptibility genes with a major effect on anorexia nervosa (AN) or bulimia nervosa (BN) have been identified. BDNF has been implicated in the regulation of food intake and body weight in rodents. A strong association has been reported of the Met-66 allele of the Val-66-Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients. Met-66 variant is strongly associated to all ED subtypes (AN ANR binge-eating/purging AN and BN) in European patients. Another single nucleotide polymorphism located in the promoter region of the BDNF gene showed an effect on BN and late age at onset of weight loss. These are two variants associated with the pathophysiology of ED in different populations. These variants support a role for BDNF in the susceptibility to aberrant eating behaviors.

Belongs to the NGF-beta family.