Synaptophysin

GWB-D9D6E3

A synthetic peptide corresponding to residues in human Synaptophysin was used as an immunogen.

WB: 1:1 000 - 10 000ICC: 1:250 - 500FC: 1:20IP: 1:50. Synaptophysin is an integral membrane protein of small synaptic vesicles in brain and endocrine cells (1). Synaptophysin (syp I) is a synaptic vesicle membrane protein that constitutes approximately 7% of the total vesicle protein. Multiple lines of evidence implicate syp I in a number of nerve terminal functions (2). Synaptophysin is one of the most abundant membrane proteins of small synaptic vesicles. In mature nerve terminals it forms a complex with the vesicular membrane protein synaptobrevin which appears to modulate synaptobrevin\' s interaction with the plasma membrane-associated proteins syntaxin and SNAP25 to form the SNARE complex as a prerequisite for membrane fusion. It has been shown that synaptobrevin is preferentially cleaved by tetanus toxin while bound to synaptophysin or when existing as a homodimer (3). data suggest that synaptophysin is released from the Golgi apparatus in a vesicular form after glycosylation and is then transported to nerve endings by a mechanism which requires integrity of microtubules (4). 1. Ozcelik T et al. Am J Hum Genet 47(3):551-61 1990. 2. McMahon HT et al. Proc Natl Acad Sci 93(10):4760-4 1996. 3. Reisinger C et al. J. Neurochem 90(1):1-8 2004. 4. Tixier-Vidal A et al. Neuroscience 26(3):847-61 1988. 5. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487