Synaptophysin (C-term)

GWB-757A80

A synthetic peptide corresponding to residues in C-terminus (cytoplasmic domain) of human Synaptophysin was used as immunogen. Predicted to cross-react with bovine based on sequence homology.

WB: 1:10 000 - 50 000IHC: 1:250-500ICC: 1:250. Synaptophysin (SypI) also referred as p38 (1) constitutSyp I contains four transmembrane regions and can be phosphorylated on its cytoplasmic C-terminus by both serine/threonine and tyrosine kinases (2). In addition to syp I synaptic vesicles contain a highly homologous membrane protein named synaptoporin or synaptophysin II (Syp II) (3). While Syp I is ubiquitously expressed and present in virtually all synapses whereas Syp II is expressed at high levels only in selected neurons (4). es approximately 7% of the total vesicle protein and is selectively associated with small synaptic vesicles (SSVs) 1. Chng WJ Remstein ED Fonseca R et al Gene expression profiling of pulmonary mucosa-associated lymphoid tissue lymphoma identifies new biologic insights with potential diagnostic and therapeutic applications Blood 113 (2009) 635 - 645[Application: ]2. Vareille M Rannou F Thelier N et al Heme Oxygenase-1 Is a Critical Regulator of Nitric Oxide Production in Enterohemorrhagic Escherichia coli-Infected Human Enterocytes The Journal of Immunology 180 (2008) 5720-5726[Application: ICC]3. Wunderlich FT Luedde T Singer S et al Hepatic NF-kB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis Proceedings of the National Academy of Sciences 105 (2008) 1297-1302[Application: WB]4. McKay JS Steele SJ Ahmed G et al An antibody panel for immunohistochemical analysis of the retina in Davidsonâ ??s-fixed paraffin-embedded eyes of rats Experimental and Toxicologic Pathology 61 (2009) 91-100[Application: IHC]5. Shaftel SS Carlson TJ Olschowka JA et al Chronic Interleukin-1 Expression in Mouse Brain Leads to Leukocyte Infiltration and Neutrophil-Independent Blood-Brain Barrier Permeability without Overt Neurodegeneration The Journal of Neuroscience 27 (2007 ) 9301-9309[Application: IHC]1. Navone F Jahn R Di Gioia G Stukenbrok H Greengard P De Camilli P. J Cell Biol. 1986 Dec; 103(6 Pt 1):2511-272. Linstedt A. D. Vetter M. L. Bishop J. M. & Kelly R. B. (1992) J. Cell Biol. 117 1077-1084. 3. Knaus P. Marqueze-Pouey B. Scherer H. & Betz H. (1990) Neuron 5 453-462. 4. Marqueze-Pouey B. Wisden W. Malosio M. L. & Betz H. (1991) J. Neurosci. 11 3388-3397. 5. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487