BDNF

ArtNr	18-272-196607
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Oncology Antibodies Western Blot Primary Antibodies By Organ Lung Cancer
Typ	Antibody
Applikationen	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-2F6D6D
Similar products	18-272-196607
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Genway ID:	GWB-2F6D6D
Immunogen:	Recombinant fragment (Human).
Antigen Species:	Human
Target:	BDNF
Localization:	Cytoplasmic and Secreted
Concentration:	0. 5 mg/ml Storage
Buffer:	PBS pH 7. 2 containing 50% glycerol 1% BSA and 0. 02% thimerosal
Application Note:	WB: Use at a concentration of 0. 5 - 1 µ g/ml. Predicted
Molecular Weight:	28 kDa. Used in conjunction with compatible secondary reagents the detection limit for recombinant hBDNF is 1. 5 - 3. 0 ng/lane under either reducing or non-reducing conditions. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cytoplasmic and Secreted Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes NGF NT3 and NT4. All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level. BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro including neural crest and placode-derived sensory neurons dopaminergic neurons in the substantia nigra basal forebrain cholinergic neurons hippocampal neurons and retinal ganglial cells. BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields raising the possibility that BDNF has paracrine or even autocrine actions on neurons as well as non-neuronal cells.
Function:	Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP) long-term depression (LTD) certain forms of short-term synaptic plasticity as well as homeostatic regulation of intrinsic neuronal excitability.
Subunit:	Monomers and homodimers. Binds to NTRK2/TRKB.
Subcellular Location:	Secreted.
Ptm:	The propeptide is N-glycosylated and glycosulfated.
Ptm:	Converted into mature BDNF by plasmin (PLG) (By similarity).
Polymorphism:	Variations in BDNF are associated with susceptybility to bulimia nervosa 2 (BULN2) [MIM:610269]. Several genes with an essential role in the regulation of eating behavior and body weight are considered candidates involved in the etiology of eating disorders (ED) but no relevant susceptibility genes with a major effect on anorexia nervosa (AN) or bulimia nervosa (BN) have been identified. BDNF has been implicated in the regulation of food intake and body weight in rodents. A strong association has been reported of the Met-66 allele of the Val-66-Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients. Met-66 variant is strongly associated to all ED subtypes (AN ANR binge-eating/purging AN and BN) in European patients. Another single nucleotide polymorphism located in the promoter region of the BDNF gene showed an effect on BN and late age at onset of weight loss. These are two variants associated with the pathophysiology of ED in different populations. These variants support a role for BDNF in the susceptibility to aberrant eating behaviors.
Disease:	Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases.
Similarity:	Belongs to the NGF-beta family.

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Menge: 0.05 mg

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Lieferung vsl. bis 11.09.2025