RABBIT ANTI HUMAN BDNF:Biotin

GWB-3C3A13

Polyclonal IgG

Recognises human BDNF (brain-derived neurotrophic factor) a potent neurotrophin and member of the NGF-beta family secreted from dense core vesicles which promotes the growth differentiation and survival of neurons within or directly connected to the central nervous system (CNS). BDNF signals through binding to the high affinity receptor trkB and also binds to the low affinity neurotrophin receptor LNGFR. Studies have shown the involvement of BDNF in the modulation of short-term synaptic function and in the formation of long-term memory and reduced levels of BDNF are seen in patients with Alzheimer\' s and Huntington disease. Recommended Secondary Antibodies: STREPTAVIDIN

Variations in BDNF are associated with susceptibility to bulimia nervosa 2 (BULN2) [MIM:610269]. Several genes with an essential role in the regulation of eating behavior and body weight are considered candidates involved in the etiology of eating disorders (ED) but no relevant susceptibility genes with a major effect on anorexia nervosa (AN) or bulimia nervosa (BN) have been identified. BDNF has been implicated in the regulation of food intake and body weight in rodents. A strong association has been reported of the Met-66 allele of the Val-66-Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients. Met-66 variant is strongly associated to all ED subtypes (AN ANR binge-eating/purging AN and BN) in European patients. Another single nucleotide polymorphism located in the promoter region of the BDNF gene showed an effect on BN and late age at onset of weight loss. These are two variants associated with the pathophysiology of ED in different populations. These variants support a role for BDNF in the susceptibility to aberrant eating behaviors. Involvement in diseaseDefects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases. Ref. 23Haploinsufficiency of BDNF is strongly associated with Wilms tumor aniridia genitourinary anomalies mental retardation and obesity syndrome (WAGRO) [MIM:612469]. In a subgroup of individuals with the WAGR syndrome obesity develops. The phenotype in this subset is associated with haploinsufficiency for the BDNF gene. Ref. 18Sequence similaritiesBelongs to the NGF-beta family. 1. Spaggiari G. M. et al. (2002) Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: evidence for a negative regulation exerted by members of the inhibitory receptor superfamily. Blood. 99: 1706 - 1714. 2. Spaggiari G. M. et al. (2002) Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction. Blood: 100: 4098 - 4107. [1] \" Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. \" Colonna M. Samaridis J. Science 268:405-408(1995) [PubMed: 7716543] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Natural killer cell. [2] \" Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. \" Wagtmann N. Biassoni R. Cantoni C. Verdiani S. Malnati M. S. Vitale M. Bottino C. Moretta L. Moretta A. Long E. O. Immunity 2:439-449(1995) [PubMed: 7749980] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] PROTEIN SEQUENCE OF 22-45. Tissue: Natural killer cell. [3] \" Human diversity in killer cell inhibitory receptor genes. \" Uhrberg M. Valiante N. M. Shum B. P. Shilling H. G. Lienert-Weidenbach K. Corliss B. Tyan D. Lanier L. L. Parham P. Immunity 7:753-763(1997) [PubMed: 9430221] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANTS. [4] \" An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. \" Yu M. -C. Su L. -L. Zou L. Liu Y. Wu N. Kong L. Zhuang Z. -H. Sun L. Liu H. P. Hu J. -H. Li D. Strominger J. L. Zang J. -W. Pei G. Ge B. -X. Nat. Immunol. 9:898-907(2008) [PubMed: 18604210] [Abstract]Cited for: FUNCTION INTERACTION WITH ARRB2; PTPN6 AND PTPN11 MUTAGENESIS OF TYR-302 AND TYR-332. [5] \" Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors. \" Fan Q. R. Mosyak L. Winter C. C. Wagtmann N. Long E. O. Wiley D. C. Nature 389:96-100(1997) [PubMed: 9288975] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1. 7 ANGSTROMS) OF 27-221.