Mouse Anti-Human CD57

GWB-42A9BB

NK-1

Purified antibody& #8804; & #956; g/106 cells

Flow Cytometry: 10 uL/10^6 cells

Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR) asialo-fetuin and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid regardless of the length of the acyl group (By similarity).

Protein modification; protein glycosylation.

Golgi apparatus membrane; Single-pass type II membrane protein.

Belongs to the glycosyltransferase 43 family. Knapp W. B. Dorken W. R. GIlks E. P. Rieber R. E. Schmidt H. Stein A. E. G. K. Von dem Borne eds. 1989. Leukocyte Typing IV: White Cell Differentiation Antigens Oxford University Press Oxford. Schlossman S. L. Bloumsell W. Gilks J. M. Harlan C. Kishimoto J. Ritz S. Shaw R. Silverstein T. Springer T. F. Tedder and R. F. Todd eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens Oxford University Press Oxford. Barclay A. N. M. H. Brown S. K. A. Law A. J. McKnight M. G. Tomlinson and P. A. van der Merwe eds. 1997. The Leukocyte Antigens Facts Book 2nd Edition CD57 Section Academic Press New York p. 287. Abo T. and C. M. Balch. 1981. J. Immunol. 127:1024. Abo T. M. D. Cooper and C. M. Balch. 1982. J. Immunol. 129:1752. d\' Angeac A. D. S. Monier D. Pilling A. Travaglio-Encinoza T. Reme and M. Salmon. 1994. Eur. J. Immunol. 24:1503.