Sox2-TAT, Human

Sox2 is a member of the Sox family of transcription factors involved in mammalian development containing a highly conserved 79-residue DNA-binding domain, known as the high mobility group (HMG) box. Sox2 is a transcription factor that forms a trimeric complex with Oct4 and binds to DNA to promote the expression of pluripotent genes involved in self-renewal, while repressing genes involved in cell differentiation. Due to its high pluripotency, Sox2 is a commonly used transcription factor for generating induced-pluripotent stem cells (iPSCs).
Recombinant Human Sox2-TAT produced in HEK293 cells is a polypeptide chain containing 330 amino acids. The rhSox2-TAT has a molecular mass of 50-55 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.

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USA