TECK/CCL25, Human

ArtNr	Z02847-1
Hersteller	GenScript
Menge	1 mg
Kategorie	Oncology Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Migration & Invasion By Organ Bone Cancer
Typ	Proteins
Format	Sterile Filtered White lyophilized (freeze-dried) powder.
Purity	>97% by SDS-PAGE and HPLC analyses.
Sequence	QGVFEDCCLA YHYPIGWAVL RRAWTYRIQE VSGSCNLPAA IFYLPKRHRK VCGNPKSREV QRAMKLLDAR NKVFAKLHHN MQTFQAGPHA VKKLSSGNSK LSSSKFSNPI SSSRKNVSLL ISANSGL
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02847-TECK_CCL25_Human, CCL25 (thymus expressed chemokine) is a novel CC chemokine that is distantly related (approximately 20% amino acid sequence identity) to other CC chemokines. Mouse CCL25 cDNA has also been cloned and shown to encode a 144 aa protein that exhibits 49% aa sequence identity to human CCL25. The expresssion of human and mouse CCL25 was shown to be highly restricted to the thymus and small intestine. Although dendritic cells have been demonstrated to be the source of CCL25 production in the thymus, dendritic cells derived from bone marrow do not express CCL25. Recombinant human and mouse CCL25 have been shown to be chemotactic for activated macrophages, dendritic cells and thymocytes. CCL25 signals through the CCR9 receptor.</td></tr><tr><th>M.W.</th><td colspan="7"> 14.2 kDa, a single, non-glycosylated polypeptide chain containing 127 amino acids. </td></tr><tr><th>Purity</th><td colspan="7"> >97% by SDS-PAGE and HPLC analyses. </td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.2EU/ug of rHuTECK/CCL25 as determined by LAL method. </td></tr><tr><th>Specific Activity</th><td colspan="7"> Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human monocytes is less than 10 ng/ml, corresponding to a specific activity of &
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Specificity	Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human monocytes is less than 10 ng/ml, corresponding to a specific activity of ＞, 1.0 x 105 IU/mg.
Specificity	Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human monocytes is less than 10 ng/ml, corresponding to a specific activity of ＞, 1.0 x 105 IU/mg.
Description	CCL25 (thymus expressed chemokine) is a novel CC chemokine that is distantly related (approximately 20% amino acid sequence identity) to other CC chemokines. Mouse CCL25 cDNA has also been cloned and shown to encode a 144 aa protein that exhibits 49% aa sequence identity to human CCL25. The expresssion of human and mouse CCL25 was shown to be highly restricted to the thymus and small intestine. Although dendritic cells have been demonstrated to be the source of CCL25 production in the thymus, dendritic cells derived from bone marrow do not express CCL25. Recombinant human and mouse CCL25 have been shown to be chemotactic for activated macrophages, dendritic cells and thymocytes. CCL25 signals through the CCR9 receptor.
Endotoxin Level	Less than 0.2EU/ug of rHuTECK/CCL25 as determined by LAL method.
Formulation	Lyophilized from a 0.2µ, m filtered concentrated, solution in 20mM PB, pH 7.4, 150mM NaCl.
M.W.	14.2 kDa, a single, non-glycosylated polypeptide chain containing 127 amino acids.
Product Line	Cytokine, Chemokines & Growth Factors
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20°, C. Further dilutions should be made in appropriate buffered solutions.
Storage	This lyophilized preparation is stable for several weeks at 2-8C, but should be kept at -20C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -70C. Avoid repeated freeze/thaw cycles.
Usage	This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Manufacturers Category	Proteins
Manufacturers Product Line	Chemokines
Product Origin	USA

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Z02847-1-datasheet.pdf

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Menge: 1 mg

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Lieferung vsl. bis 24.07.2025