IL-20, Human

180,00 €

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ArtNr	Z02714-10
Hersteller	GenScript
Menge	10 ug
Kategorie	Oncology Neuroscience Neuroinflammation By Cell Type Hematology Leukemia Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Cell Status Cytoskeleton Proliferation Intermediate filaments By Organ Heart & Blood Cancer
Typ	Proteins
Format	Sterile Filtered White lyophilized (freeze-dried) powder.
Specific against	Human (Homo sapiens)
Purity	>95% by SDS-PAGE and HPLC analyses.
Sequence	MLKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTESLQDTKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA NSFLTIKKDLRLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVKALG ELDILLQWME ETE
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02714-Interleukin-20_IL-20_Human, IL-20 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20R-ª and type II IL-20R-ß. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease.</td></tr><tr><th>M.W.</th><td colspan="7"> Approximately 17.6 kDa, a single non-glycosylated polypeptide chain containing 153 amino acids.</td></tr><tr><th>Purity</th><td colspan="7"> >95% by SDS-PAGE and HPLC analyses.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.2EU/ug of rHuIL-20 as determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> Fully biologically active when compared to standard. The ED50 determined by a cell proliferation assay using human IL-20R&
Similar products	Interleukin-20
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Specificity	Fully biologically active when compared to standard. The ED50 determined by a cell proliferation assay using human IL-20Rα, and human IL-20Rβ, co-transfected murine BaF3 pro-B cells is less than 0.6 ng/ml, corresponding to a specific activity of &
Specificity	Fully biologically active when compared to standard. The ED50 determined by a cell proliferation assay using human IL-20Rα, and human IL-20Rβ, co-transfected murine BaF3 pro-B cells is less than 0.6 ng/ml, corresponding to a specific activity of ＞, 1.7 x 106 IU/mg.
Description	IL-20 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20R-ª and type II IL-20R-ß. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease.
Endotoxin Level	Less than 0.2EU/ug of rHuIL-20 as determined by LAL method.
Formulation	Lyophilized from a 0.2µ, m filtered concentrated, solution in PBS, pH 7.4.
M.W.	Approximately 17.6 kDa, a single non-glycosylated polypeptide chain containing 153 amino acids.
Product Line	Cytokine, Chemokines & Growth Factors
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °, C. Further dilutions should be made in appropriate buffered solutions.
Storage	This lyophilized preparation is stable for several weeks at 2-8 C, but should be kept at -20 C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 C to -70 C. Avoid repeated freeze/thaw cycles.
Usage	This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Manufacturers Category	Proteins
Manufacturers Product Line	Cytokines
Product Origin	USA

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Menge: 10 ug

Listenpreis: 180,00 €

Preis: 180,00 €

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