TNF-α, His, Human

Tumor Necrosis Factor-Alpha (TNF-alpha), plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases. Besides inducing hemorrhagic necrosis of tumors, TNF has been found to be involved in tumorigenesis, tumor metastasis, viral replication, septic shock, fever, inflammation, and autoimmune diseases including Crohn's disease, and rheumatoid arthritis as well as graft-versus-host disease. TNF alpha-1a is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells.Recombinant, human Tumor Necrosis Factor-Alpha (rhTNF-alpha), produced in E. coli is a non-glycosylated polypeptide chain of 164 amino acids. A fully biologically active molecule, rhTNF-alpha, has a molecular mass of 18.3kDa analyzed by reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.

Lyophilized after extensive dialysis against PBS.

Cytokine, Chemokines & Growth Factors

Lyophilized recombinant, human Tumor Necrosis Factor-Alpha (rhTNF-alpha), remains stable up to 12 months at -80C from date of receipt. Upon reconstitution, rhTNF-alpha should be stable up to 4 weeks at 4C or up to 6 months at -20C.

Cytokines