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Recombinant Human Aflatoxin B1 aldehyde reductase member 3(AKR7A3)

Recombinant Human Aflatoxin B1 aldehyde reductase member 3(AKR7A3)

ArtNr	CSB-EP001551HU-10
Hersteller	Cusabio
Menge	10ug
Kategorie	Food Safety Mycotoxins Peptides & Proteins Recombinant Proteins
Typ	Proteins
Specific against	other
Host	E.coli
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	AFB1 aldehyde reductase 2
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Research Topic	Signal Transduction
Uniprot ID	O95154
Gene Names	AKR7A3
Organism	Homo sapiens (Human)
AA Sequence	MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAF LERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDC RVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCP RVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVEL GLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAI TRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYK YEDKDGKQPVGRFFGNTWAEMYRNRYWKEHHFEGI ALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGA HGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAF NQAWHLVAHECPNYFR
Expression Region	1-331aa
Sequence Info	Full Length of BC025709
Source	E.coli
Tag Info	N-terminal GST-tagged
MW	64.2 kDa
Alternative Name(s)	AFB1 aldehyde reductase 2
Relevance	Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Reference	"cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3." Knight L.P., Primiano T., Groopman J.D., Kensler T.W., Sutter T.R. Carcinogenesis 20:1215-1223(1999)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Subcellular Location	Cytoplasm
Protein Families	Aldo/keto reductase family, Aldo/keto reductase 2 subfamily
Tissue Specificity	Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.

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