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Recombinant Mouse C-C motif chemokine 5 protein(Ccl5) (Active)

Recombinant Mouse C-C motif chemokine 5 protein(Ccl5) (Active)

873,00 €

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ArtNr	CSB-AP001241MO-100
Hersteller	Cusabio
Menge	100ug
Kategorie	Oncology Food Safety Histamines Neuroscience Neuroinflammation Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Peptides & Proteins Recombinant Proteins By Organ Pancreatic Cancer
Typ	Proteins Recombinant
Specific against	other
Host	E.coli
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	MuRantes, Small-inducible cytokine A5, T-cell-specific protein RANTES
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Classification	Cytokine
Subdivision	Chemokine
Research Areas	Immunology
Uniprot NO.	P30882
Uniprot Entry Name	CCL5_MOUSE
Gene Names	Ccl5, Scya5
Source	E.Coli
Expression Region	24-91aa
Sequence	SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SS KCSNLAVV FVTRRNRQVC ANPEKKWVQE YINY LEMS
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	7.9 kDa
Biological Activity	Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T lymphocytes is in a concentration range of 1.0-10 ng/ml.
Purity	>97% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Alias	MuRantes, Small-inducible cytokine A5, T-cell-specific protein RANTES
Relevance	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. {ECO:0000250\|UniProtKB:P13501}.
PubMed ID	1375672; 1376260; 7507961; 7513046; 10438970; 16141072; 15489334
Function	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
Subcellular Location	Secreted
Protein Families	Intercrine beta (chemokine CC) family
Tissue Specificity	T-cell and macrophage specific.

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