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Recombinant Human Galectin-1 protein(LGALS1) (Active)

Recombinant Human Galectin-1 protein(LGALS1) (Active)

972,00 €

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ArtNr	CSB-AP000471HU-500
Hersteller	Cusabio
Menge	500ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
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Classification	Others
Subdivision	Others
Research Areas	Cancer
Uniprot NO.	P09382
Uniprot Entry Name	LEG1_HUMAN
Gene Names	LGALS1
Source	E.Coli
Expression Region	2-135aa
Sequence	ACGLVASNLN LKPGECLRVR GEVAPDAKSF VL NLGKDSNN LCLHFNPRFN AHGDANTIVC NSKD GGAWGT EQREAVFPFQ PGSVAEVCIT FDQANL TVKL PDGYEFKFPN RLNLEAINYM AADGDFKI KC VAFD
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	14.6 kDa
Biological Activity	Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human blood monocytes is in a concentration range of 1.0-10 ng/ml.
Purity	>95% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered 20 mM PB, pH 7.4, 150mM NaCl , lyophilized
Alias	Gal-1, HLBP14, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin
Relevance	May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. {ECO:0000269\|PubMed:14617626, ECO:0000269\|PubMed:18796645, ECO:0000269\|PubMed:19497882}.
PubMed ID	2719964; 2910856; 2719646; 18824694; 1988031; 12761501; 15461802; 14702039; 10591208; 15489334; 3065332; 12665801; 3611046; 1386213; 2383549; 7501023; 10369126; 10764829; 11146440; 14617626; 19497882; 19608861; 21269460; 22905912; 22223895; 22814378; 23131994; 24275569; 26091039; 15476813; 18796645; 19128029
Function	Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Subcellular Location	Secreted, extracellular space, extracellular matrix
Tissue Specificity	Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 500ug

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