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THOC1 Antibody

173,00 €
Zzgl. MwSt.
ArtNr CSB-PA853419ESR1HU-50ul
Hersteller Cusabio
Menge 50ul
Kategorie
Typ Antibody Polyclonal
Format Liquid
Applikationen WB, IHC, ELISA, CHIP
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host Rabbit
Isotype IgG
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84), THOC1, HPR1
Similar products THOC1, HPR1, THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84)
Lieferbar
Aliases
THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84), THOC1, HPR1
Immunogen Species
Human
UniprotID
Q96FV9
Immunogen
Recombinant Human THO complex subunit 1 protein (428-657AA)
Applications info
ELISA, WB, IHC, ChIP, Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200
Dilution ratio 1
ELISA:1:2000-1:10000
Dilution ratio 2
WB:1:1000-1:5000
Dilution ratio 3
IHC:1:20-1:200
Background
Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Stroage
Upon receipt, store at -20C or -80C. Avoid repeated freeze.
Purification Method
Antigen Affinity Purified
Target Names
THOC1
General Research Areas
Epigenetics and Nuclear Signaling, Tags & Cell Markers
Initial Research Areas
Tags & Cell Markers

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50ul
Lieferbar: In stock
Listenpreis: 173,00 €
Preis: 173,00 €
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Lieferung vsl. bis 28.08.2025 

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