Native Human Holo-Transferrin

Human Holo Transferrin (Transferrin iron-saturated, Siderophilin, tf, TRF) SDS-Polyacrylamide gel electrophoresis shows one major band only corresponding to the molecular weight of human Transferrin. Human Transferrin is a plasma protein for iron ion delivery. Human Transferrin is a glycoprotein with homologous N-terminal and C-terminal iron binding domains. Transferrin (TF) is related to other iron binding proteins including lactoferrin. When human transferrin loaded with iron encounters a transferrin receptor on the surface of a cell, it binds to it and is consequently transported into the cell in a vesicle. The cell will acidify the vesicle, causing human transferrin (TF) to release its iron ions. Each human transferrin molecule has the ability to carry two iron ions in the ferric form (Fe3+).

77 kDa