Anti-BDNF Antibody

366,00 €

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ArtNr	BOS-PA1014
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Antibodies Obesity Western Blot Primary Antibodies By Organ Brain Cancer Neuronal Cell Markers
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	1. Jones, K. R.; Reichardt, L. F. : Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc. Nat. Acad. Sci. 87: 8060-8064, 1990. 2. Lee, R.; Kermani, P.; Teng, K. K.; Hempstead, B. L. : Regulation of cell survival by secreted proneurotrophins. Science 294: 1945-1948, 2001 . 3. Pruunsild, P.; Kazantseva, A.; Aid, T.; Palm, K.; Timmusk, T. : Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics 90: 397-406, 2007.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Brain-derived neurotrophic factor;BDNF;Abrineurin;BDNF;
Similar products	Abrineurin antibody, BDNF antibody, BDNF_HUMAN antibody, Brain Derived Neurotrophic Factor antibody, Brain-derived neurotrophic factor antibody, MGC34632 antibody, Neurotrophin antibody
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Specificity	No cross reactivity with other proteins.
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Neurology Process, Neuroscience, Obesity
Short Description	Boster Bio Anti-BDNF Antibody catalog # PA1014. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-BDNF Antibody catalog # PA1014. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Background	Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes NGF, NT3, and NT4. BDNF is a prosurvival factor induced by cortical neurons that is necessary for survival of striatal neurons in the brain. BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields. BDNF has been purified and shown to reduce the amount of naturally occurring neuronal cell death in portions of the peripheral nervous system.
Gene Name	BDNF
Application Details	Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
Application Notes	Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Predicted Reactivity	Hamster
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminal of human BDNF, identical to the related rat and mouse sequences.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Brain-derived neurotrophic factor
Molecular Weight	27818 MW
Protein Function	During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability..
Subcellular Localization	Secreted.
Tissue Specificity	Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta..
Protein Name	Brain-derived neurotrophic factor(BDNF)
Sequence Similarities	Belongs to the NGF-beta family.

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