Recombinant Mouse Interleukin-36 beta protein (Il36b) (Active)

Interleukin-1 family member 8,

E.coli

SSQSPRNYRV HDSQQMVWVL TGNTLTAVPA SN NVKPVILS LIACRDTEFQ DVKKGNLVFL GIKN RNLCFC CVEMEGKPTL QLKEVDIMNL YKERKA QKAF LFYHGIEGST SVFQSVLYPG WFIATSSI ER QTIILTHQRG KLVNTNFYIE SEK

Tag-Free

>97% as determined by SDS-PAGE and HPLC.

Less than 1.0 EU/ug as determined by LAL method.

Ice packs

1 year

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T helper 1 (Th1) cells, cultured CD4(+) T cells and splenocytes. {ECO:0000250|UniProtKB:Q9NZH7, ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679}.

Secreted