CD3 zeta (K36) polyclonal antibody

P20963

Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. CD3-zeta forms either homodimers or heterodimers with CD3-eta. Interacts with SLA and SLA2. Interacts with DOCK2 and TRAT1. Interacts with HIV-1, this interaction up-regulates the expression of the Fas ligand (FASLG) at the cell surface. Interacts with HIV-2 Nef protein, this interaction induces down-regulation of cell surface TCR/CD3 complexes.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

CD3 zeta (K36) pAb detects endogenous levels of CD3 zetaprotein.

For research use only, not for use in diagnostic procedure.

Synthetic peptide, corresponding to the N-terminus of Human CD3 zeta.