Animal-Free TGF alpha/TGFA Protein, Human (His)

TGF alpha/TGFA protein, a mitogenic polypeptide, binds to EGFR and synergistically acts with TGF beta to promote anchorage-independent cell proliferation. Its interactions with MAGI3, SDCBP, and SNTA1 PDZ domains, especially with SDCBP, are crucial for effective cell surface targeting. In its immature endoplasmic reticulum form, characterized by a prosegment and lacking full N-glycosylation, TGF alpha/TGFA interacts with CNIH. Furthermore, in the Golgi apparatus, it may form a complex with CNIH and GORASP2. Additionally, its cytoplasmic C-terminal domain interacts with NKD2, showcasing diverse functional roles in cellular compartments and interactions. Animal-Free TGF alpha/TGFA Protein, Human (His) is the recombinant human-derived animal-FreeTGF alpha/TGFA protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free TGF alpha/TGFA Protein, Human (His) is 50 a.a., with molecular weight of ~6.49 kDa.

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Recombinant Proteins