Human ICOS ELISA Kit PicoKine®

PicoKine® ELISA Kits

Human ICOS ELISA Kit PicoKine® (96 Tests). Quantitate Human ICOS in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 2pg/ml.

Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene. The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.

Dilution ratio of 1:1, concentration in serum and plasma is less than the lowest standard, 62.5 pg/ml.

There is no detectable cross-reactivity with other relevant proteins.

monoclonal antibody from mouse|biotinylated polyclonal antibody from goat

heparin or EDTA

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.