« Zurück
Startseite /
Anti-Histamine H3 receptor HRH3 Antibody

Anti-Histamine H3 receptor HRH3 Antibody

366,00 €

Zzgl. MwSt.

ArtNr	BOS-PA1204
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Food Safety Histamines Neuroscience Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Antibodies Obesity Western Blot Cardiovascular Research Hypertension Primary Antibodies By Organ Brain Cancer Other Lipid\Cholesterol Metabolism Modulators
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Histamine H3 receptor;H3R;HH3R;G-protein coupled receptor 97;HRH3;GPCR97;
Similar products	G protein coupled receptor 97 antibody, G-protein coupled receptor 97 antibody, GPCR 97 antibody, GPCR97 antibody, H3R antibody, HH 3R antibody, HH3 R antibody, HH3R antibody, Histamine H3 receptor antibody, Histamine receptor H3 antibody, HRH 3 antibody, HRH3 antibody, HRH3_HUMAN antibody, OTTHUMP00000031459 antibody
Lieferbar
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	More Gpcr, Neuroscience, Neurotransmission, Receptors / Channels
Short Description	Boster Bio Anti-Histamine H3 receptor HRH3 Antibody catalog # PA1204. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-Histamine H3 receptor HRH3 Antibody catalog # PA1204. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Background	The histamine receptor H3 (HRH3) is a presynaptic autoreceptor on histamine neurons in the brain and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. The deduced 445-amino acid HRH3 protein contains 7 predicted transmembrane domains. And it shares 22% and 21.4% amino acid sequence homology with the H1 (HRH1) and H2 (HRH2) receptors, respectively. The expression of recombinant HRH3 in a variety of cell lines conferred an ability to inhibit adenylate cyclase in response to histamine, but not to acetylcholine or any other biogenic amine. Additionally, HRH3 was most notably observed throughout the thalamus, the ventromedial hypothalamus, and the caudate nucleus. Strong expression was also seen in layers II, V, and VIb of the cerebral cortex, in the pyramidal layers of the hippocampus, and in olfactory tubercle.
Gene Name	HRH3
Application Details	Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
Application Notes	Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Predicted Reactivity	Bovine
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human HRH3, different from the related rat sequence by three amino acids.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Histamine H3 receptor
Molecular Weight	48671 MW
Protein Function	The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
Subcellular Localization	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.
Protein Name	Histamine H3 receptor(H3R/HH3R)

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.