Anti-Human Ki-67 Monoclonal Antibody

Cancer, Cell Biology, Cell Cycle, Cell Division, Cell Type Marker, Cell Type Markers, Neurogenesis, Neurology Process, Neuron Marker, Neuroscience, Tags & Cell Markers, Tumor Biomarkers

Boster Bio Anti-Human Ki-67 Monoclonal Antibody catalog # M00254-1. Tested in IF, ICC, WB applications. This antibody reacts with Human.

Monoclonal

Affinity purified antibody at 1mg/mL in 50% PBS, 50% glycerol, 5mM azide

Recombinant construct containing the 2nd, 3rd and 4th Ki67 repeats of the human sequence (amino acids 1, 111-1, 490) expressed in and purified from E. coli.

Proliferation marker protein Ki-67

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable)..