ICOS polyclonal antibody

Q9Y6W8

The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells. CD80 and CD86 bind to the homologous T cell receptors CD28 and CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. ICOS (inducible co-stimulator) is related to CD28 and CTLA-4, and these three proteins are thought to compose a receptor family. ICOS stimulation enhances T cell responses and superinduces the synthesis of IL-10, but it does not induce IL-2 upregulation.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

ICOS pAb detects endogenous levels of ICOS protein.

Immunofluorescence analysis of MCF7 cells, using ICOS polyclonal antibody

For research use only, not for use in diagnostic procedure.

Recombinant full length Human ICOS.