FSHR polyclonal antibody

P23945

Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G-protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its alpha and beta subunits. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, the beta subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome, a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

FSHR pAb detects endogenous levels of FSHR protein.

ca. 78 kDa

Follicle-stimulating hormone receptor, FSH-R, Follitropin receptor, LGR1