TNFSF14 polyclonal antibody

O43557

Herpes virus entry mediator (HVEM), a type I transmembrane protein, is a member of the TNF receptor superfamily. HVEM mediates the entry of herpes simplex virus (HSV) 1 and 2 into T lymphocytes by serving as an attachment site for the HSV envelope glycoprotein D (gD). HVEM also binds two cellular ligands, secreted lymphotoxin alpha and light. LIGHT is a member of the TNF superfamily produced by activated T cells. This type II transmembrane protein competes with HSV glycoprotein D for binding to HVEM. LIGHT is closely related in sequence to lymphotoxin beta (LTbeta) and can also bind to the LTbeta receptor. LIGHT is also known to induce apoptosis and suppress tumor formation.The gene encoding LIGHT maps to human chromosome 19p13.3.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

TNFSF14 pAb detects endogenous levels of TNFSF14 protein.

ca. 26 kDa

Tumor necrosis factor ligand superfamily member 14, Herpes virus entry mediator ligand, HVEM-L, Herpesvirus entry mediator ligand, CD258, Cleaved into the following 2 chains, Tumor necrosis factor ligand superfamily member 14, membrane form, Tumor necrosis factor ligand superfamily member 14, soluble form, TNFSF14, HVEML, LIGHT, UNQ391, PRO726