TNFRSF14 polyclonal antibody

Q92956

HVEM (herpes virus entry mediator A), also known as TR2, ATAR, HVEA, LIGHTR or TNFRSF14 (tumor necrosis factor receptor superfamily, member 14), is a 283 amino acid single-pass type I membrane protein that is widely expressed, with highest expression in lung, spleen and thymus. A member of the TNF receptor superfamily, HVEM mediates the entry of herpes simplex virus (HSV) 1 and 2 into T lymphocytes by serving as an attachment site for the HSV envelope glycoprotein D (gD).HVEM acts as a receptor for two cellular ligands, secreted lymphotoxin and LIGHT. A member of the TNF superfamily produced by activated T-cell, LIGHT is suggested to induce apoptosis and suppress tumor formation. Consisting of three TNFR-Cys repeats, HVEM plays a critical role in HSV pathogenesis. HVEM is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3, 000 genes and comprises nearly 8% of the human genome.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

TNFRSF14 pAb detects endogenous levels of TNFRSF14 protein.

ca. 31 kDa

Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Herpesvirus entry mediator A, HveA, Tumor necrosis factor receptor-like 2, TR2, CD270, TNFRSF14, HVEA, HVEM, UNQ329/PRO509