Anti-Mouse CD152 (CTLA-4) PE Size 25 ug

The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator.

The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.

The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Alegre, M. L., Noel, P. J., Eisfelder, B. J., Chuang, E., Clark, M. R., Reiner, S. L., & Thompson, C. B. (1996). Regulation of surface and intracellular expression of CTLA4 on mouse T cells. The Journal of Immunology, 157(11), 4762-4770.

Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., ... & Bluestone, J. A. (1994). CTLA-4 can function as a negative regulator of T cell activation. Immunity, 1(5), 405-413.

Cilio, C. M., Daws, M. R., Malashicheva, A., Sentman, C. L., & Holmberg, D. (1998). Cytotoxic T Lymphocyte Antigen 4 Is Induced in the Thymus upon In Vivo Activation and Its Blockade Prevents Anti-CD3-"mediated Depletion of Thymocytes. The Journal of experimental medicine, 188(7), 1239-1246.