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MBD1 Peptide (AAP40168)

151,00 €
Zzgl. MwSt.
ArtNr AAP40168
Hersteller AVIVA Systems Biology
Menge 100 ug
Kategorie
Typ Peptides
Format Lyophilized powder
Applikationen WB
Specific against other
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Similar products MBD1
Lieferbar
Description
This is a synthetic peptide designed for use in combination with anti-MBD1 antibody (Catalog #: ARP40168_T100) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Gene symbol
MBD1
Protein size
549
Molecular weight
60kDa
Product format
Lyophilized powder
Gene id
4152
Reconstitution and storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Partner proteins
ATF7IP, ATF7IP2, CHAF1A, SETDB1, ATF7IP, ATF7IP2, CBX5, CHAF1A, HDAC3, HIPK3, OASL, PIAS1, PIAS2, SETDB1, SMAD1, SMAD3, SMAD5, SMAD7, SMAD9, SUV39H1, ATF7IP, CBX4, CBX5, CHAF1A, RNF2, Rnf2, SUV39H1
Description of target
MBD1 belongs to a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD1 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
Listenpreis: 151,00 €
Preis: 151,00 €
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Lieferung vsl. bis 28.08.2025 

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